Reviewed by a health professional. It is originally used as an explosive, a pesticide, as well as a range of other industrial processes including- dye, wood preserver, herbicide and photographic developer. This causes the mitochondria to use more energy to create ATP, thus, increasing the metabolic rate and increasing caloric expenditure which leads to weight loss 4. In recent years, there has been a resurgence of DNP use, largely in the bodybuilding community.
DNP can assist in weight loss. This is the main reported benefit of DNP usage, and it does this through several associated mechanisms listed below. DNP increases the metabolic rate by stimulating the uncoupling of oxidative phosphorylation This causes the cell to undergo more ATP production to meet energy demands.
Since the production of ATP actually costs energy, this results in a greater metabolic rate, thereby leading to weight loss DNP also causes an increase in internal heat production By altering the electrochemical gradient of protons in favor of producing less ATP, the result is more energy being lost as heat production instead of conversion to ATP This increase in heat production leads to an increase in caloric consumption, which again leads to weight loss DNP causes an upregulation in glycolysis Researchers found that the combination of the stimulation of glycolysis and the inhibition of uncoupling resulted in a large increase in carbohydrate depletion 16 All of these mechanisms serve the same purpose: to decrease the efficiency of energy production as a means of increasing energy expenditure.
However, these mechanisms greatly disturb normal cell function and are all potentially lethal DNP may have promising effects on age-related neurological disorders according to recent research. The research is preliminary and has not yet been tested in humans, but it certainly warrants further examination. One study used rat models to assess the effects of DNP use after suffering an ischemic stroke.
DNP was shown to reduce impact volume thereby reducing the damage done by the stroke This is, of course, an important finding that may have benefits in reducing impairment after suffering a stroke. In all three scenarios, there is existing mitochondrial dysfunction, which the DNP appears to regulate 2425 Also, the researchers are not exactly sure of the mechanism by which DNP is acting to regulate the mitochondrial function.
It is also important to note that these studies all used rat models and are one-of-kind, so much further research is needed to determine the safety and efficacy of DNP use in the treatment of certain neurological disorders. DNP makes dieting somewhat effortless. DNP decreases carb tolerance. Low carb diets have shown time and time again to be an effective weight loss agent. DNP causes an inability to handle large amounts of carbohydrates and often forces users to go lower carb. This often results in even more weight loss.
DNP can combat liver disease. Unfortunately, there are no approved drugs for treating this condition. DNP can help with diabetes. According to Examine, Dinitrophenol, by mitochondrial uncoupling, is able to protect mitochondria from Reactive-Oxygen Species ROS mediated cell death by allowing energy to be lost through uncoupling rather than contained in the mitochondria to exert damage.
This was demonstrated in an animal model injected with a toxic dose of quinolinic acid DNP can cause cardiovascular failure. The decreased efficiency of ATP production inevitably leads to an increase in internal body temperature The DNP fat loss plan involves a 7-day on, 7-day off approach with four distinct phases.
Most athletes using DNP follow this type of cycle. The phases are as follows:. Phase 1: The 3-day Carb-Depletion Phase. Phase 1. The 3-day Carb-depletion phase Phase One has a three-day duration and begins the four days preceding the ingestion of DNP.
The purpose of this phase is to deplete muscle-glycogen content by restricting carbohydrates. This is achieved through a Ketogenic style diet. Kcals should be restricted to times bodyweight in lbs. Protein is consumed at 1 gram per pound of bodyweight or higher and the remaining dietary calories should come from fat.
This phase lasts exactly 3 days, and will reduce muscle-glycogen levels so that the body is forced to rely on fat as fuel more readily when you start your DNP cycle. During the past three days, the athlete has restricted carbohydrates and as a direct consequence T4-T3 conversion is slowed down resulting in reduced T3 levels.
Day four of the DNP cycle involves a mega-carbohydrate meal at mid-afternoon PM designed to create a massive insulin spike and re-normalize T4-T3.
This concept has been extrapolated from ketogenic diets and has been shown to dramatically increase serum concentrations of T3. Day 4 involves Keto eating until the Mega-carb meal.
Then in the late afternoon, at least circa g of carbohydrates must be consumed to create an insulin spike.
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Any sugar fructose, sucrose, maltose etc. Fructose in particular is good because it primarily re-fills liver glycogen which is directly involved in T4-T3 conversion. Empty liver glycogen signals the thyroid to decrease T4-T3 conversion. As a side-note, a g carb-meal after three days of Keto dieting creates a more pronounced insulin spike than would a g carb-meal after three days of normal eating. Kcals during Phase 2 should be kept at 15X Bodyweight in lbs.
Macro-nutrient break-downs can be calculated by the athlete. The only carb intake on day 4 should be the g carb-meal.
The first two days of actual DNP consumption are the most important to follow correctly. During Days 1 and 2 of the actual DNP portion of the cycle, it must be determined if the athlete will have an allergic reaction to DNP. At this point the dieter should be able to assess if an allergic reaction has occurred.
A DNP-stimulated allergic reaction will lead to swelling in as little as 1 to 2 days time.Enter your email and we'll keep you on top of the latest nutrition research, supplement myths, and more. Our evidence-based analysis on 2,4-dinitrophenol features 23 unique references to scientific papers. Each member of our research team is required to have no conflicts of interest, including with supplement manufacturers, food companies, and industry funders.
The team includes nutrition researchers, registered dietitians, physicians, and pharmacists. We have a strict editorial process. This page features 23 references. All factual claims are followed by specifically-applicable references.
Click here to see the full set of references for this page. Dinitrophenol is an ionophoric compound that short circuits mitochondrial ATP production. This cessation of ATP production via the mitochondria leads to an increase in the metabolic rate as substrate is utilized at a higher rate so cytosolic ATP can sustain life and subsequent weight loss.
It is one of the few chemical compounds that is causatively linked to death. Overdosing on Dinitrophenol leads to toxicity via excessive heat production, irregular breathing and heartrate, and mitochondrial dysfunction.
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Standard online protocols advice for titrating up towards a dose of mg daily with cessation after 2 weeks of usage.
NOTE: This dosing information is anecdotal in nature and is based on past human trials that were not conducted in a controlled fashion. No information exists in the scientific literature for the best dosages for weight loss. Tired of misinformation? Get unbiased info on supplements.
At Examine. We take an independent, unbiased approach to figure out what works and what's a waste of time and money. Arm yourself with the knowledge you need to make the right decisions about your health. Click here to see the full set of research information and references for 2,4-Dinitrophenol. If using any pharmaceuticals or drugs given to you by a doctor or received with a prescription, you must consult with the doctor in question or an equally qualified Health Care Professional prior to using any nutritional supplementation.This guide will be focusing on the correct dosage to use while using DNP.
Each individual will react differently to different doses for a multitude of reasons, but the biggest factor is the weight of the person on cycle. If you have not read my paper on how DNP works please do so here before continuing.
Why weight is the main factor. DNP works by interacting with the mitochondria within your cells. The more DNP that is flowing in and out of your mitochondria the harder your body will have to work to maintain production of ATP. A low active blood concentration is not necessarily a bad thing.
Even if you are not experiencing a significant amount of sides it is still working.RE : DNP The CONTROVERSY is STRONG!!!! ( Warning Informational Purposes ONLY)
Too high of a concentration and the sides will be unbearable and could lead to negative consequences. You can think of active blood concentration as a drop of food coloring in water. The concentration will be much higher if you put a drop in an 8oz glass of water as opposed to putting one in a gallon of water.
The same can be said for 2 individuals of different size. A lb How do I calculate my daily dosage? Start by converting your weight into kg. So for a lb individual you would take and multiply it by 0.
To figure this out simply take the estimated daily dose and divide by your weight. We will be limiting the calculations to 2 decimal places. Dosage Ranges. These ranges are not for everyone, but are based off of different logs and also personal experience. This will let you know if you will have a negative reaction to the chemical.
Remain at this dose for 5 days. Remain at this dose for the remaining 9 days and then take a 2 week break before continuing to subsequent cycles. Subsequent Cycles - These dosage ranges will give you an idea of the side-effects you should expect. It is still very manageable, but your diet starts having a significant effect on the amount of sides experienced.The dosage calculator finds what dose of a medication is appropriate for your weight.
Read on to learn what the drug dosage calculation formula is and how to use it. With our text, you will also learn more about the various different kinds of dosing which you may encounter when using different medications. You will also find out what the advantages are of adjusting the dose to the patient. Are you looking for a healthy dose of antipyretic medication for kids? Make sure to take a look at our ibuprofen dosage calculator and the paracetamol dosage calculator!
Depending on the route of administration, dosage forms come in several different types.
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The most popular route of administration is oral, however, in some medical situations this route is unavailable, ineffective or associated with a high number of adverse reactions. That is why patients may receive drugs through parenteral means this includes: subcutaneous, intramuscular, intraosseous, intravenous, etc.
Moreover, some drugs are only given topically - they're applied directly onto the skin or eye, into the rectum or vagina, or as an inhalation.
You should know that the route of administration of a drug dramatically influences its dosage and efficacy. You should thus always check if you are administering the appropriate drug to the appropriate person through the appropriate route in the appropriate dose!
When treating a patient, or just taking a medication by yourself, we always need to wonder what is the exact dose of the drug we choose.
And the truth is that we dose or should dose nearly everything in our life, from cooking dinner to taking medications! One dosage Drugs with one fix dosage are the easiest in use; you just take it and forget about it e. You don't need to use any dosage calculation formulas! Different, fixed dosages The dosage of these drugs is usually set by the doctor according to the patient's needs or age e.
In this case you also don't have to worry about medical dosage calculations! Blood concentration-dependent dosages This is a relatively small group of drugs. The doses are different depending on the concentration of the drug's active compound in the serum.
Vitamin K antagonists, lithium.
DNP RESULTS....Low Dosages Work!
The dosage of the drug depends on the patient's body weight The dose of the drug depend on the weight of the patient. It means, that two patients with the same disease may receive a different amount of the same drug! Our dosage calculator will help you calculate appropriate doses of this kind of drugs! The right dose differentiates a poison and a remedy. This sentence is still holds today. We know that every substance, especially drugs, may be toxic if given in an inappropriate dose.
This is why we should perform our dosage calculations carefully and accurately.
This is especially critical when administering drugs to childrenas a slight mistake in the dose may cause a significant change in the effect of its action. The usage of a pediatric dose calculator seems to be a responsible choice that reduces the risk of a mistake! Contemporary scientists are also looking at the issue of drug dosage. There are plenty of on-going clinical trials in which different doses of the drugs are being compared. Moreover, there are more and more scientific data suggesting that individually performed dosage calculations not only in pediatric patients improve patient survival when compared with a standard treatment of fixed doses.
For instance, in a group of scientists from France published an article in the Journal of Clinical Oncology in which they summarized the results of their clinical trial on patients with metastatic colorectal cancer cancer of large bowel in the IV stage of the disease - with metastases.
The group that was treated with an individually adjusted dose of fluorouracil antimetabolite drug used in the treatment of many cancers, including colon cancer had a better response to the therapy, a higher survival rate and a lower grade of toxicitythan those treated with standard doses.
Medical dosage calculations that consider a patient's weight are very common in obese patients and on pediatric wards.Log in Register.
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If I had to describe DNP in one word…poison. DNP prevents normal chemical reactions at the cellular level.
It impedes the normal function of cellular metabolism. Where did DNP Come from? DNP was found to have other properties that made it useful for making dyes, wood preservatives, photographic developer, and pesticides. DNP is highly toxic, and people working with or around the substance can develop side effects like weight loss, high fever, and death. The weight loss aspect prompted studies regarding the effects of DNP on metabolism.
How does DNP work? DNP makes changes in our metabolism. Metabolism is the set of chemical reactions in our bodies that keep us alive. Our bodies metabolize nutrients to provide us with energy. Oxidation involves the transfer of electrons between atoms or molecules and releases energy. The formal name for this process is oxidative phosphorylation.
In order to create ATP, mitochondria capture and use the energy released from oxidative phosphorylation. DNP is known as a mitochondrial uncoupler of oxidative phosphorylation. The energy released from DNP action is converted into heat energy.